Anxiety in oncology outpatients is associated with perturbations in pathways identified in anxiety focused network pharmacology research.

ABSTRACT:

Purpose

Evaluate for perturbed signaling pathways associated with subgroups of patients with low versus high levels of state anxiety. These pathways were compared to the pathways identified across eight network pharmacology studies of the anxiolytic effect(s) of a variety of compounds.

Methods

Adult outpatients had a diagnosis of breast, gastrointestinal, gynecological, or lung cancer; had received chemotherapy within the preceding four weeks; and were scheduled to receive at least two additional cycles of chemotherapy. Latent profile analysis was used to identify subgroups of patients with distinct anxiety profiles based on Spielberger State Anxiety Inventory scores that were obtained six times over two cycles of chemotherapy. Blood samples were processed using RNA sequenci

SUBMITTER: Oppegaard K 

PROVIDER: S-EPMC10682221 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature