Characteristics of insulin resistance in Korean adults from the perspective of circadian and metabolic sensing genes.

ABSTRACT:

Background

The biological clock allows an organism to anticipate periodic environmental changes and adjust its physiology and behavior accordingly.

Objective

This retrospective cross-sectional study examined circadian gene polymorphisms and clinical characteristics associated with insulin resistance (IR).

Methods

We analyzed data from 1,404 Korean adults aged 30 to 55 with no history of cancer and cardio-cerebrovascular disease. The population was classified according to sex and homeostasis model assessment of insulin resistance (HOMA-IR) values. Demographics, anthropometric and clinical characteristics, and single nucleotide polymorphisms (SNPs) were analyzed with respect to sex, age, and HOMA-IR values. We used association rule mining to identify sets of SNPs from c

SUBMITTER: Park MS 

PROVIDER: S-EPMC10682234 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature