Exponential dosing to standardize myocardial perfusion image quality with rubidium-82 PET.

ABSTRACT:

Background

⁸²Rb PET is commonly performed using the same injected activity in all patients, resulting in lower image quality in larger patients. This study compared ⁸²Rb dosing with exponential vs proportional functions of body weight on the standardization of myocardial perfusion image (MPI) quality.

Methods

Two sequential cohorts of N = 60 patients were matched by patient weight. Rest and dipyridamole stress ⁸²Rb PET was performed using 0.1 MBq·kg^-2 exponential and 9 MBq·kg^-1 proportional dosing. MPI scans were compared qualitatively with visual image quality scoring (IQS) and quantitatively using the myocardium-to-blood contrast-to-noise ratio (CNR) and blood background signal-to-noise ratio (SNR) as a function of bod

SUBMITTER: Tavoosi A 

PROVIDER: S-EPMC10682245 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature