Validation of the novel Eosinophilic Esophagitis Impact Questionnaire.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) has a detrimental effect on health-related quality of life (HRQOL). The Eosinophilic Esophagitis Impact Questionnaire (EoE-IQ) is a novel patient-reported outcome (PRO) measure assessing the impact of EoE on HRQOL. To assess suitability of the EoE-IQ, its measurement properties were evaluated.

Methods

Using baseline and week 24 data from the pivotal, randomized, placebo-controlled, multinational phase 3 R668-EE-1774 trial (NCT03633617) of dupilumab, we evaluated EoE-IQ's measurement properties (including reliability, construct and known-groups validity, and ability to detect change) and established the threshold for change in scores that can be considered clinically meaningful.

Results

The analysis population comprised 239 adu

SUBMITTER: McCann E 

PROVIDER: S-EPMC10682344 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature