Pangenomic and immunoinformatics based analysis of Nipah virus revealed CD4⁺ and CD8⁺ T-Cell epitopes as potential vaccine candidates.

ABSTRACT: Introduction: Nipah (NiV) is the zoonotic deadly bat-borne virus that causes neurological and respiratory infections which ultimately lead to death. There are 706 infected cases reported up till now especially in Asia, out of which 409 patients died. There is no vaccine and effective treatment available for NiV infections and we have to timely design such strategies as world could not bear another pandemic situation. Methods: In this study, we screened viral proteins of NiV strains based on pangenomics analysis, antigenicity, molecular weight, and sub-cellular localization. The immunoproteomics based approach was used to predict T-cell epitopes of MHC class-I and II as potential vaccine candidates. These epitopes are capable to activate CD4⁺, CD8⁺, and T

SUBMITTER: Muhammad SA 

PROVIDER: S-EPMC10682379 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature