Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue.

ABSTRACT: Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study has shown that the secondary motor cortex carries two types of representations: place cell-like activity, which were impaired by hippocampal lesions, and responses tied to visuo-tactile cues, which became more pronounced following hippocampal lesions. Using two-photon Ca²⁺ imaging to record neuronal activities in the secondary motor cortex of male Thy1-GCaMP6s mice, we assessed the cortical retrieval of spatial and non-spatial attributes

SUBMITTER: Chang H 

PROVIDER: S-EPMC10682454 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature