Distribution characteristics of circulating B cell subpopulations in patients with chronic kidney disease.

ABSTRACT: This study compared the levels of circulating B cell subpopulations in patients with different stages of chronic kidney disease (CKD), investigated the effects of haemodialysis (HD) on the B cell-related immune spectrum in patients with end-stage renal disease, and evaluated the link between renal function and immune homeostasis. Overall, 197 patients with CKD (158 non-dialysis patients with CKD stages I-V and 39 end-stage patients undergoing maintenance HD) and 77 healthy controls were included. Compared to healthy controls, patients with CKD stages I-II showed no significant differences except for the proportion of transitional B cells; patients with CKD stage V showed a significant decrease in the proportions of transitional B cells and CD5⁺ B cells and a significant increase

SUBMITTER: Chen X 

PROVIDER: S-EPMC10682455 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature