Mutual modulation of gut microbiota and the immune system in type 1 diabetes models.

ABSTRACT: The transgenic 116C-NOD mouse strain exhibits a prevalent Th17 phenotype, and reduced type 1 diabetes (T1D) compared to non-obese diabetic (NOD) mice. A cohousing experiment between both models revealed lower T1D incidence in NOD mice cohoused with 116C-NOD, associated with gut microbiota changes, reduced intestinal permeability, shifts in T and B cell subsets, and a transition from Th1 to Th17 responses. Distinct gut bacterial signatures were linked to T1D in each group. Using a RAG-2^-/- genetic background, we found that T cell alterations promoted segmented filamentous bacteria proliferation in young NOD and 116C-NOD, as well as in immunodeficient NOD.RAG-2^-/- and 116C-NOD.RAG-2^-/- mice across all ages. Bifidobacterium colonization depended on lymphocytes

SUBMITTER: Rosell-Mases E 

PROVIDER: S-EPMC10682479 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature