In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men.

ABSTRACT: The regional integrity of brain subcortical structures has been implicated in sleep-wake regulation, however, their associations with sleep parameters remain largely unexplored. Here, we assessed association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem and the variability in the sleep electrophysiology in a large sample of 18-to-31 years healthy young men (N = 321; ~ 22 years). Separate Generalized Additive Model for Location, Scale and Shape (GAMLSS) revealed that sleep onset latency and slow wave energy were significantly associated with MTsat estimates in the brainstem (p_corrected ≤ 0.03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, how

SUBMITTER: Talwar P 

PROVIDER: S-EPMC10682495 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature