Higher mortality among lean patients with non-alcoholic fatty liver disease despite fewer metabolic comorbidities.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) can develop in individuals who are not overweight. Whether lean persons with NAFLD have lower mortality and lower incidence of cirrhosis, cardiovascular diseases (CVD), diabetes mellitus (DM) and cancer than overweight/obese persons with NAFLD remains inconclusive. We compared mortality and incidence of cirrhosis, CVD, DM and cancer between lean versus non-lean persons with NAFLD.

Methods

This is a retrospective study of adults with NAFLD in a single centre from 2012 to 2021. Primary outcomes were mortality and new diagnosis of cirrhosis, CVD, DM and cancer. Outcomes were modelled using competing risk analysis and Cox proportional hazards regression analysis.

Results

A total of 18,594 and 13,420 patients were

SUBMITTER: Wijarnpreecha K 

PROVIDER: S-EPMC10682563 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature