The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.

ABSTRACT: Photoaging is the main form of external skin aging, and ultraviolet radiation is the main cause. Long-term ultraviolet radiation can cause oxidative stress, inflammation, immune responses, and skin cell apoptosis. Therefore, it is necessary to explore active products from plants to treat skin photoaging. C57BL/6J mice were randomly divided into control, model, and purslane (Portulaca oleracea L.) extract-treated groups (150, 300, and 600 mg/kg). Ultraviolet (UV) radiation induces skin photoaging. Histopathological changes in the skin were observed by hematoxylin and eosin (H&E), Masson's trichrome, and toluidine staining. Levels of hydroxyproline (HYP), hyaluronic acid (HA), collagen I (COL1), catalase (CAT), malondialdehyde (MDA), and total superoxide dismutase (T-SOD) were measure

SUBMITTER: Qu L 

PROVIDER: S-EPMC10682634 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature