Anticancer and anti-metastasis activity of 1,25 dihydroxycholecalciferols and genistein in MCF-7 and MDA-MB-231 breast cancer cell lines.

ABSTRACT: A powerful steroid hormone precursor, 1,25 dihydroxycholecalciferols (1,25(OH)₂D₃), and dietary phytoestrogen (genistein) are essential compounds that act by binding to nuclear receptors and altering gene expression. They have many biological benefits, some of which have anticancer properties. We studied the impact of 1,25(OH)₂D₃ and genistein on the proliferation, progression, and metastasis of MCF-7 and MDA-MB-231 cells when they were used alone or in combination and investigated whether there was a synergistic effect between genistein and 1,25(OH)₂D₃. To achieve these goals, a variety of assays, including flow cytometry, cell invasion assays, cell adhesion assays, Western blotting, and RT‒PCR, were used. Our findings show

SUBMITTER: Alatawi FS 

PROVIDER: S-EPMC10682641 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature