Exploring clonality and virulence gene associations in bloodstream infections using whole-genome sequencing and clinical data.

ABSTRACT:

Background

Bloodstream infections (BSIs) remain a significant cause of mortality worldwide. Causative pathogens are routinely identified and susceptibility tested but only very rarely investigated for their resistance genes, virulence factors, and clonality. Our aim was to gain insight into the clonality patterns of different species causing BSI and the clinical relevance of distinct virulence genes.

Methods

For this study, we whole-genome-sequenced over 400 randomly selected important pathogens isolated from blood cultures in our diagnostic department between 2016 and 2021. Genomic data on virulence factors, resistance genes, and clonality were cross-linked with in-vitro data and demographic and clinical information.

Results

The investigation yielded extensive

SUBMITTER: Neidhofer C 

PROVIDER: S-EPMC10682671 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature