Metastatic lymph node burden impacts overall survival in submandibular gland cancer.

ABSTRACT:

Objective

To assess the effect of the number of positive lymph nodes (LNs) on the overall survival (OS) of patients with submandibular gland cancer (SmGC).

Methods

Patients who had undergone neck dissection for SmGC were retrospectively enrolled in this study. The effect of the American Joint Committee on Cancer (AJCC) N stage, the number of positive LNs, LN size, LN ratio, and extranodal extension (ENE) on OS and recurrence-free survival (RFS) was evaluated using Cox analysis. Prognostic models were proposed based on the identified significant variable, and their performance was compared using hazard consistency and discrimination.

Results

In total, 129 patients were included in this study. The number of positive LNs rather than LN ratio, LN size, and ENE was associa

SUBMITTER: Wang L 

PROVIDER: S-EPMC10682759 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature