Mutations of RAS genes identified in acute myeloid leukemia affect glycerophospholipid metabolism pathway.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a malignant disease originating from myeloid hematopoietic stem cells. Recent studies have shown that certain gene mutations promote tumor cell survival and affect the prognosis of patients by affecting metabolic mechanisms in tumor cells. RAS gene mutations are prevalent in AML, and the RAS signaling pathway is closely related to many metabolic pathways. However, the effects of different RAS gene mutations on AML cell metabolism are unclear.

Objectives

The main purpose of this study was to explore the effect of RAS gene mutation on the metabolic pathway of tumor cells.

Methods

In this study, we first used a retrovirus carrying a mutant gene to prepare Ba/F3 cell lines with RAS gene mutation

SUBMITTER: Liang T 

PROVIDER: S-EPMC10682766 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature