Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny.

ABSTRACT: Group B flavin-dependent monooxygenases are employed in swathes of different physiological functions. Despite their collectively large substrate profile, they all harness a flavin-based C4a-(hydro)peroxy intermediate for function. Within this class are the flavin-containing monooxygenases (FMOs), representing an integral component within the secondary metabolism of all living things - xenobiotic detoxification. Their broad substrate profile makes them ideal candidates for detoxifying procedures as they can tackle a range of compounds. Recent studies have illustrated that several FMOs, however, have unique substrate profiles and differing physiological functions that implicate new roles within secondary and primary metabolism. Herein this article, by employing phylogenetic approaches

SUBMITTER: Nicoll CR 

PROVIDER: S-EPMC10682829 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature