Plasma tumour necrosis factor-alpha-related proteins in prognosis of heart failure with pulmonary hypertension.

ABSTRACT:

Aims

Patients with heart failure (HF) exhibit poor prognosis, which is further deteriorated by pulmonary hypertension (PH), with negative impact on morbidity and mortality. As PH due to left HF (LHF-PH) is among the most common causes of PH, there is an urge according to the 2021 European Society of Cardiology HF guidelines to find new biomarkers that aid in prognostication of this patient cohort. Given the role of tumour necrosis factor-alpha (TNF-α) in HF progression, we aimed to investigate the prognostic value of plasma proteins related to TNF-α in patients with LHF-PH, in relation to haemodynamic changes following heart transplantation (HT).

Methods and results

Twenty TNF-α-related plasma proteins were analysed using proximity extension assay in healthy controls (n = 20

SUBMITTER: Engel Sallberg A 

PROVIDER: S-EPMC10682849 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature