Circulating microRNAs and cardiomyocyte proliferation in heart failure patients related to 10 years survival.

ABSTRACT:

Aims

Mechanochemical signalling drives organogenesis and is highly conserved in mammal evolution. Regaining recovery in myocardial jeopardy by inducing principles linking cardiovascular therapy and clinical outcome has been the dream of scientists for decades. Concepts involving embryonic pathways to regenerate adult failing hearts became popular in the early millennium. Since then, abundant data on stem cell research have been published, never reaching widespread application in heart failure therapy. Another conceptual access, using mechanotransduction in cardiac veins to limit myocardial decay, is pressure-controlled intermittent coronary sinus occlusion (PICSO). Recently, we reported acute molecular signs and signals of PICSO activating regulatory miRNA and inducing cell prolife

SUBMITTER: Wagh V 

PROVIDER: S-EPMC10682869 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature