Activation of AHR by ITE improves cardiac remodelling and function in rats after myocardial infarction.

ABSTRACT:

Aims

Left ventricular remodelling subsequent to myocardial infarction (MI) constitutes a pivotal underlying cause of heart failure. Intervention with the nontoxic endogenous aryl hydrocarbon receptor (AHR) agonist 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) in the acute phase of MI has been shown to ameliorate cardiac function, but its role in the chronic phase remains obscured. This study explores the beneficial role of ITE in delaying the progression of heart failure in the chronic phase of MI.

Methods and results

MI rats established by ligating the left anterior descending coronary artery were treated with the indicated concentration of the AHR agonist ITE or vehicle alone. Echocardiography was performed to determine cardiac structure and func

SUBMITTER: Lin X 

PROVIDER: S-EPMC10682871 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature