Association of hypoxic burden metrics with cardiovascular outcomes in heart failure and sleep-disordered breathing.

ABSTRACT:

Aims

Heart failure (HF) and sleep-disordered breathing (SDB) frequently coexist. We aimed to compare the prognostic value of different nocturnal hypoxic burden metrics in hospitalized HF patients.

Methods and results

HF patients underwent polygraphy screening for SDB in this prospective cohort. Hypoxic burden metrics assessed using pulse oximetry included time < 90% oxygen saturation (T90), proportion of total recording time < 90% oxygen saturation (TRT90), oxygen desaturation index (ODI), and mean oxygen saturation (meanSO₂ ). The prespecified endpoints were the composite of cardiovascular death or admission for worsening HF. This study included 764 hospitalized HF patients, 16.5% and 36.6% of whom had obstructive and central sleep apnoea, respectively. With a me

SUBMITTER: Huang B 

PROVIDER: S-EPMC10682880 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature