Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left-sided heart diseases.

ABSTRACT:

Aims

The pathophysiology of pulmonary hypertension (PH) due to left-sided heart disease (Group 2 PH) is distinct from that of other groups of PH, yet there are still no approved therapies that selectively target pulmonary circulation. The increase in pulmonary capillary pressure due to left-sided heart disease is a trigger event for physical and biological alterations of the pulmonary circulation, including the nitric oxide (NO)-soluble guanylate cyclase-cyclic guanosine monophosphate axis. This study investigated inhaled NO vasoreactivity tests for patients with Group 2 PH and hypothesized that these changes may have a prognostic impact.

Methods and results

This was a single-centre, retrospective study with a median follow-up of 365 days. From January 2011 to December 2015,

SUBMITTER: Satoh T 

PROVIDER: S-EPMC10682891 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature