Long-term impact of angiotensin receptor-neprilysin inhibitor based on short-term treatment response in heart failure.

ABSTRACT:

Aims

The long-term effect of angiotensin receptor-neprilysin inhibitor (ARNI) remains uncertain in patients who have experienced improvements in left ventricular (LV) systolic function or significant LV reverse remodelling following a certain period of treatment. It is also unclear how ARNI performs in patients who have not shown these improvements. This study aimed to assess the impact of prolonged ARNI use compared with angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) in patients with and without significant treatment response after 1 year of heart failure (HF) treatment.

Methods and results

The present study enrolled patients with HF with reduced ejection fraction (HFrEF) who were treated with either ARNI or ACEIs/ARBs within 1 year of

SUBMITTER: Park HK 

PROVIDER: S-EPMC10682893 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature