Conduction system pacing and atrioventricular node ablation in heart failure: The PACE-FIB study design.

ABSTRACT:

Aims

Atrial fibrillation (AF) worsens the prognosis of patients with heart failure (HF). Successful treatments are still very scarce for those with permanent AF and preserved (HFpEF) or mildly reduced (HFmrEF) ejection fraction. In this study, the long-term benefits and safety profile of heart rate regularization through left-bundle branch pacing (LBBP) and atrioventricular node ablation (AVNA) will be explored in comparison with pharmacological rate-control strategy.

Methods and results

The PACE-FIB trial is a multicentre, prospective, open-label, randomized (1:1) clinical study that will take place between March 2022 and February 2027. A total of 334 patients with HFpEF/HFmrEF and permanent AF will receive either LBBP followed by AVNA (intervention arm) or optimal pharmaco

SUBMITTER: Rodriguez Munoz D 

PROVIDER: S-EPMC10682904 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature