Genetically predicted androgenic profiles and adverse cardiac markers: a sex-specific Mendelian randomization study.

ABSTRACT:

Aims

Observational evidence suggests associations between sex hormone levels and heart failure (HF). We used sex-specific genetic variants associated with androgenic sex hormone profiles to investigate the causal relevance of androgenic sex hormone profiles on cardiac structure and function and HF using Mendelian randomization (MR).

Methods and results

Sex-specific uncorrelated genome-wide significant (P < 5 × 10^-8 ) variants predicting sex hormone-binding globulin (SHBG), total testosterone, and bioavailable testosterone were extracted from summary statistics of genome-wide association study (GWAS) on 425 097 participants in the UK Biobank. Sex-specific gene-outcome association estimates were computed for left ventricular ejection fraction (LVEF), left ventricula

SUBMITTER: Chen JY 

PROVIDER: S-EPMC10682908 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature