Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.

ABSTRACT: The orientation of mouse hair follicles is controlled by the planar cell polarity (PCP) pathway. Mutations in PCP genes result in two categories of hair mis-orientation phenotype: randomly oriented and vertically oriented to the skin surface. Here, we demonstrate that the randomly oriented hair phenotype observed in frizzled 6 (Fzd6) mutants results from a partial loss of the polarity, due to the functional redundancy of another closely related frizzled gene, Fzd3 Double knockout of Fzd3 and Fzd6 globally, or only in the skin, led to vertically oriented hair follicles and a total loss of anterior-posterior polarity. Furthermore, we provide evidence that, contrary to the prevailing model, asymmetrical localization of the Fzd6 protein is not observed in skin epith

SUBMITTER: Dong B 

PROVIDER: S-EPMC10682934 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature