Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization.

ABSTRACT:

Background

The secretome of mesenchymal stromal cells isolated from the amniotic membrane (hAMSCs) has been extensively studied for its in vitro immunomodulatory activity as well as for the treatment of several preclinical models of immune-related disorders. The bioactive molecules within the hAMSCs secretome are capable of modulating the immune response and thus contribute to stimulating regenerative processes. At present, only a few studies have attempted to define the composition of the secretome, and several approaches, including multi-omics, are underway in an attempt to precisely define its composition and possibly identify key factors responsible for the therapeutic effect.

Methods

In this study, we characterized the protein composition of the hAMSCs secretome by a fi

SUBMITTER: Muntiu A 

PROVIDER: S-EPMC10683150 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature