Extending the 'host response' paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities.

ABSTRACT: Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac output state that is the conditio sine qua non of the clinical syndrome. This approach has failed to translate into improved outcomes, and mortality has remained static at 30-50%. There is an unmet need to better delineate the pathobiology of CS to understand the observed heterogeneity of presentation and treatment effect and to identify novel therapeutic targets. Despite data in other critical illness syndromes, specifically sepsis, the role of dysregulated inflammation and immunity is hitherto poorly described in CS. High-dimensional molecular profiling, particularly through leukocyte transcriptomics, may afford opportunity to better characterise subgroups of patient

SUBMITTER: Buckel M 

PROVIDER: S-EPMC10683227 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature