External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock.

ABSTRACT:

Background

Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identification of high-risk patients can facilitate targeted intervention to improve outcomes. We previously modified the renal angina index (RAI), a validated AKI prediction tool, to improve specificity in this population (sRAI). Here, we prospectively assess sRAI performance in a separate cohort.

Methods

A secondary analysis of a prospective, multicenter, observational study of children with septic shock admitted to the pediatric intensive care unit from 1/2019 to 12/2022. The primary outcome was severe AKI (≥ KDIGO Stage 2) on Day 3 (D3 severe AKI), and we compared predictive performance of the sRAI (calculated on Day 1) to the original RAI and serum

SUBMITTER: Stanski NL 

PROVIDER: S-EPMC10683237 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature