Chromosome-scale genome of the human blood fluke Schistosoma mekongi and its implications for public health.

ABSTRACT:

Background

Schistosoma mekongi is a human blood fluke causing schistosomiasis that threatens approximately 1.5 million humans in the world. Nonetheless, the limited available S. mekongi genomic resources have hindered understanding of its biology and parasite-host interactions for disease management and pathogen control. The aim of our study was to integrate multiple technologies to construct a high-quality chromosome-level assembly of the S. mekongi genome.

Methods

The reference genome for S. mekongi was generated through integrating Illumina, PacBio sequencing, 10 × Genomics linked-read sequencing, and high-throughput chromosome conformation capture (Hi-C) methods. In this study, we conducted de novo assembly, alignment, and gene prediction to assemble and annotate the gen

SUBMITTER: Zhou M 

PROVIDER: S-EPMC10683246 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature