Inflammatory bowel disease and bladder cancer risk: based on a Mendelian randomization study.

ABSTRACT:

Background

Prior epidemiological observational studies have duly documented a correlative link between inflammatory bowel disease (IBD) and bladder cancer (BC); however, the establishment of a definitive causal relationship has remained elusive. The principal objective of this meticulous investigation was to rigorously evaluate the causal nexus between IBD and BC, employing the robust methodology of Mendelian randomization (MR) analysis.

Methods

We meticulously performed both univariate and multivariate Mendelian randomization (MVMR) analyses employing publicly accessible genome-wide association study (GWAS) data. The central approach employed for our investigations was inverse variance weighting (IVW) method, while diligently scrutinizing potential sources of heterogeneity

SUBMITTER: Wang L 

PROVIDER: S-EPMC10683281 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature