A novel tumor purity and immune infiltration-related model for predicting distant metastasis-free survival in prostate cancer.

ABSTRACT:

Background

umor cells, immune cells and stromal cells jointly modify tumor development and progression. We aim to explore the potential effects of tumor purity on the immune microenvironment, genetic landscape and prognosis in prostate cancer (PCa).

Methods

Tumor purity of prostate cancer patients was extracted from The cancer genome atlas (TCGA). Immune cellular proportions were calculated by the CIBERSORT. To identify critical modules related to tumor purity, we used weighted gene co-expression network analysis (WGCNA). Using STRING and Cytoscape, protein-protein interaction (PPI) networks were constructed and analyzed. A Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, Disease Ontology (DO), and Gene Set Enrichment Analysis (GSEA) enrichment ana

SUBMITTER: Su Q 

PROVIDER: S-EPMC10683297 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature