Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis.

ABSTRACT:

Background

This reconstructed individual patient data (IPD)-based meta-analysis is aimed to summarize the current findings and comprehensively investigate the predictive value of circulating tumor DNA (ctDNA) in operable non-small cell lung cancer (NSCLC).

Methods

PubMed, Cochrane and Embase were searched to include potentially eligible studies. The primary outcomes included progression-free survival (DFS) by ctDNA status at baseline, postoperative, and longitudinal timepoints. The IPD-based survival data was retracted and used in reconstructed IPD-based meta-analysis. Subgroup analysis was implemented based on the baseline characteristics.

Results

Totally, 28 studies were involved, including 15 full-length articles (1686 patients) for IPD-based synthesis and 20 studi

SUBMITTER: Chen D 

PROVIDER: S-EPMC10683311 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature