Noggin contributes to brain metastatic colonization of lung cancer cells.

ABSTRACT:

Background

Brain metastasis is a common complication among patients with lung cancer, yet the underlying mechanisms remain unclear. In this study, we aimed to investigate the pathogenesis of brain metastasis in lung cancer.

Methods

We established highly colonizing metastatic lung cancer cells, A549-M2, through multiple implantations of A549 human lung cancer cells in the carotid artery of athymic nude mice.

Results

Compared to parental cells (M0), M2 cells demonstrated slower growth in culture plates and soft agar, as well as lower motility and higher adhesion, key characteristics of mesenchymal-epithelial transition (MET). Further analysis revealed that M2 cells exhibited decreased expression of epithelial-mesenchymal transition markers, including ZEB1 and Vimentin.

SUBMITTER: Lee JE 

PROVIDER: S-EPMC10683317 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature