Clinically Translatable Hyperpolarized ¹³C Bicarbonate pH Imaging Method for Use in Prostate Cancer.

ABSTRACT: Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical prostate cancer models, disease progression is associated with a decrease in tumor extracellular pH, suggesting that pH imaging may reflect an imaging biomarker to detect aggressive and high-risk disease. Therefore, we developed a hyperpolarized carbon-13 MRI method to image the tumor extracellular pH (pH_e) and prepared it for clinical translation for detection and risk stratification of PCa. This method relies on the rapid breakdown of hyperpolarized (HP) 1,2-glycerol carbonate (carbonyl-¹³C) via base-catalyzed hydrolysis to produce HP ¹³CO₃

SUBMITTER: Mu C 

PROVIDER: S-EPMC10683509 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature