Gelatin methacryloyl and Laponite bioink for 3D bioprinted organotypic tumor modeling.

ABSTRACT: Three-dimensional (3D)in vitrotumor models that can capture the pathophysiology of human tumors are essential for cancer biology and drug development. However, simulating the tumor microenvironment is still challenging because it consists of a heterogeneous mixture of various cellular components and biological factors. In this regard, current extracellular matrix (ECM)-mimicking hydrogels used in tumor tissue engineering lack physical interactions that can keep biological factors released by encapsulated cells within the hydrogel and improve paracrine interactions. Here, we developed a nanoengineered ion-covalent cross-linkable bioink to construct 3D bioprinted organotypic tumor models. The bioink was designed to implement the tumor ECM by creating an interpenetrating network compos

SUBMITTER: de Barros NR 

PROVIDER: S-EPMC10683563 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature