N7-methylguanosine-related miRNAs predict hepatocellular carcinoma prognosis and immune therapy.

ABSTRACT: N7-methylguanosine (m⁷G) modification has been notably linked with the development of many tumors. However, no investigations have been conducted on whether m⁷G-related miRNA (m⁷G-miRNA) is a prognostic index of hepatocellular carcinoma (HCC). Therefore, this investigation aimed to establish a predictive m⁷G-miRNA signature for efficient HCC prognosis and elucidate the associated immune cell infiltration (ICI) and functions in the tumor microenvironment. RNA sequencing and clinical data on 375 HCC and 50 healthy tissue samples were acquired from The Cancer Genome Atlas database. The m⁷G-miRNA regulators methyltransferase-like 1 and WD repeat domain 4 were acquired from the TargetScan database. Univariate Cox regression analysis was con

SUBMITTER: Ma L 

PROVIDER: S-EPMC10683595 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature