CCL19: a novel prognostic chemokine modulates the tumor immune microenvironment and outcomes of cancers.

ABSTRACT:

Background

CCL19 is a chemokine involved in cancer research due to its important role in the tumor microenvironment (TME) and clinical relevance in cancers. This study aimed to analyze transcription expression, genomic alteration, association with tumor immune microenvironment of CCL19 expression and its prediction value for prognosis and responses to immunotherapy for patients with cancers.

Methods

RNA sequencing data and corresponding clinicopathological information of a total of large-scale cancer patients were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. Multiplex immunofluorescence (mIF) was implemented to identify differential infiltration of Treg, CD8⁺ T cells, and tumor-associated macrophages, while CCL19 immunohistochemistr

SUBMITTER: Gu Q 

PROVIDER: S-EPMC10683612 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature