Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans.

ABSTRACT: Several studies have investigated the effect of parental age on biological parameters such as reproduction, lifespan, and health; however, the results have been inconclusive, largely due to inter-species variation and/or modest effect sizes. Here, we examined the effect of parental age on the lifespan, reproductive capacity, and locomotor activity of genetic isogenic lines of the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. We found that the progeny of successive generations of old parents had significantly shorter lifespans than the progeny of young parents in both species. Moreover, we investigated the fertility, fecundity, and locomotor activity of C. elegans. Interestingly, both the shorter lifespan and deteriorated healthspan of the p

SUBMITTER: Lenzi C 

PROVIDER: S-EPMC10683632 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature