Comprehensive analysis reveals XCL2 as a cancer prognosis and immune infiltration-related biomarker.

ABSTRACT:

Background

X-C Motif Chemokine Ligand 2 (XCL2) is a 114 amino acid, structurally conserved chemokine involved in activating cytotoxic T cells. However, the pathophysiological mechanisms of XCL2 protein in various disease conditions, particularly cancer, remain poorly understood.

Methods

Bioinformatics was used to detect the expression of XCL2, the relationship between survival time and XCL2 in BLCA patients, the mutational status of XCL2, the role of XCL2 in the tumor immune microenvironment, and the sensitivity of XCL2-targeted drugs in 33 cancers. In vitro experiments were conducted to investigate the chemotactic effects of XCL2 expression on M1-type macrophages in human specimens and in isolated cancer cells.

Results

XCL2 expression was downregulated in tumo

SUBMITTER: Chen W 

PROVIDER: S-EPMC10683633 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature