Associations between neurovascular coupling and cerebral small vessel disease: A systematic review and meta-analysis.

ABSTRACT:

Purpose

The pathogenesis of cerebral small vessel disease (cSVD) remains elusive despite evidence of an association between white matter hyperintensities (WMH) and endothelial cerebrovascular dysfunction. Neurovascular coupling (NVC) may be a practical alternative measure of endothelial function. We performed a systematic review of reported associations between NVC and cSVD.

Methods

EMBASE and PubMed were searched for studies reporting an association between any STRIVE-defined marker of cSVD and a measure of NVC during functional magnetic resonance imaging, transcranial Doppler, positron emission tomography, near-infrared spectroscopy or single-photon emission computed tomography, from inception to November 3rd, 2022. Where quantitative data was available from studies using

SUBMITTER: Yang S 

PROVIDER: S-EPMC10683738 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature