Spatial Summation in the Glaucomatous Macula: A Link With Retinal Ganglion Cell Damage.

ABSTRACT:

Purpose

The purpose of this study was to test whether functional loss in the glaucomatous macula is characterized by an enlargement of Ricco's area (RA) through the application of a computational model linking retinal ganglion cell (RGC) damage to perimetric sensitivity.

Methods

One eye from each of 29 visually healthy subjects <40 years old, 30 patients with glaucoma, and 20 age-similar controls was tested with a 10-2 grid with stimuli of 5 different area sizes. Structural estimates of point-wise RGC density were obtained from optical coherence tomography (OCT) scans. Structural and functional data from the young healthy cohort were used to estimate the parameters of a computational spatial summation model to generate a template. The template was fitted with a Bayesian hier

SUBMITTER: Montesano G 

PROVIDER: S-EPMC10683773 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature