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Volitional activation of remote place representations with a hippocampal brain-machine interface.

ABSTRACT: The hippocampus is critical for recollecting and imagining experiences. This is believed to involve voluntarily drawing from hippocampal memory representations of people, events, and places, including maplike representations of familiar environments. However, whether representations in such "cognitive maps" can be volitionally accessed is unknown. We developed a brain-machine interface to test whether rats can do so by controlling their hippocampal activity in a flexible, goal-directed, and model-based manner. We found that rats can efficiently navigate or direct objects to arbitrary goal locations within a virtual reality arena solely by activating and sustaining appropriate hippocampal representations of remote places. This provides insight into the mechanisms underlying episodic memory recall, mental simulation and planning, and imagination and opens up possibilities for high-level neural prosthetics that use hippocampal representations.

SUBMITTER: Lai C

PROVIDER: S-EPMC10683874 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Volitional activation of remote place representations with a hippocampal brain-machine interface.

Lai Chongxi C Tanaka Shinsuke S Harris Timothy D TD Lee Albert K AK

Science (New York, N.Y.) 20231102 6670

The hippocampus is critical for recollecting and imagining experiences. This is believed to involve voluntarily drawing from hippocampal memory representations of people, events, and places, including maplike representations of familiar environments. However, whether representations in such "cognitive maps" can be volitionally accessed is unknown. We developed a brain-machine interface to test whether rats can do so by controlling their hippocampal activity in a flexible, goal-directed, and mode ...[more]

PMID: 37917713

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