Injectable neural hydrogel as in vivo therapeutic delivery vehicle.

ABSTRACT:

Purpose

This study demonstrated in vivo delivery of a decellularized, injectable peripheral nerve (iPN) hydrogel and explored options for using iPN in combination with regenerative biomolecular therapies like stem cell secretome.

Methods

Rat-derived iPN hydrogel solutions were combined with a dextran-dye before subcutaneous injection into adult Sprague Dawley rats. After injection, an in vivo imaging system (IVIS) was used to visualize hydrogels and quantify dextran-dye release over time. Poly(lactic-co-glycolic) acid (PLGA) was used to encapsulate the dextran-dye to prolong molecular release from the hydrogel scaffolds. Lastly, we investigated use of adipose-derived stem cell (ASC) secretome as a potential future combination strategy with iPN. ASC secretome wa

SUBMITTER: Hlavac N 

PROVIDER: S-EPMC10683944 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature