Evaluation of Newborn Direct Bilirubin As Screening for Cholestatic Liver Disease.

ABSTRACT:

Background

Biliary atresia (BA) remains the most common indication for pediatric liver transplantation. Early diagnosis is essential for a favorable long-term prognosis for patients with BA. Preliminary data suggests that measurement of direct bilirubin (DB) in newborns may be an effective screening tool for neonatal cholestasis, particularly BA, allowing for early referral and diagnosis. The objective of our study was to establish a cutoff DB value to predict diagnosis of cholestatic liver disease (CLD) with high sensitivity and specificity, as well as, to evaluate whether newborns with elevated DB received appropriate follow-up in our health system.

Methods

Baseline data were collected on infants born between 2016 and 2019 who had serum total bilirubin and DB drawn in the

SUBMITTER: Lerer R 

PROVIDER: S-EPMC10684158 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature