Investigation of hub genes involved in Turner syndrome using biological informatics methods.

ABSTRACT:

Background

This study aimed to explore candidate genes and their potential interaction mechanism critical to the pathophysiology of Turner syndrome by using the Gene Expression Omnibus database.

Methods

GSE58435 data set was obtained by querying the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened using R and subsequently annotated by Gene Ontology. Functional enrichment analysis was performed based on the Kyoto Encyclopedia of Genes and Genomes database for annotation, visualization, and integrated discovery. A protein-protein interaction network of different genes was constructed based on the STRING database, in which hub genes were explored through Cytoscape software. The expression of the hub genes was verified by analyzing the gene e

SUBMITTER: Cheng T 

PROVIDER: S-EPMC10684194 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature