Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations.

ABSTRACT: Viola tricolor is a medicinal plant with documented application as an anti-inflammatory herb. The standard of care for the treatment of inflammatory bowel disease is immunosuppressive therapeutics or biologics, which often have undesired effects. We explored V. tricolor herbal preparations that are rich in an emerging class of phytochemicals with drug-like properties, so-called cyclotides. As an alternative to existing inflammatory bowel disease medications, cyclotides have immunomodulatory properties, and their intrinsic stability allows for application in the gastrointestinal tract, for instance, via oral administration. We optimized the isolation procedure to improve the yield of cyclotides and compared the cellular effects of violet-derived organic solvent-extracts, aqueo

SUBMITTER: Retzl B 

PROVIDER: S-EPMC10684336 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature