Drug Utilisation Patterns of Alternatives to Ranitidine-Containing Medicines in Patients Treated with Ranitidine: A Network Analysis of Data from Six European National Databases.

ABSTRACT:

Introduction

Ranitidine, a histamine H₂-receptor antagonist (H₂RA), is indicated in the management of gastric acid-related disorders. In 2020, the European Medicines Agency (EMA) recommended suspension of all ranitidine-containing medicines in the European Union (EU) due to the presence of N-nitrosodimethylamine (NDMA) impurities, which were considered to be carcinogenic. The aim of this study was to investigate the impact of regulatory intervention on use patterns of ranitidine-containing medicines and their therapeutic alternatives.

Objectives

The aim was to study drug utilisation patterns of ranitidine and report discernible trends in treatment discontinuation and switching to alternative medications.

Methods

This retrospective, population-bas

SUBMITTER: Arinze JT 

PROVIDER: S-EPMC10684403 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature