Positron emission tomography in the diagnosis and follow-up of transthyretin amyloid cardiomyopathy patients: A systematic review.

ABSTRACT:

Purpose

Transthyretin (ATTR) amyloidosis is a progressive protein misfolding disease with frequent cardiac involvement. This review aims to determine the value of PET in diagnosis, assessment of disease progression or treatment response and its relation to clinical outcome in follow-up of ATTR amyloid cardiomyopathy (ATTR-CM) patients.

Methods

Medline, Cochrane Library, Embase and Web of Science databases were searched, from the earliest date available until December 2022, for studies investigating the use of PET in ATTR-CM patients. Studies containing original data were included, except for case reports. Risk of bias was assessed by QUADAS-2.

Results

Twenty-one studies were included in this systematic review, investigating five different tracers: carbon-11 Pittsburgh

SUBMITTER: Tingen HSA 

PROVIDER: S-EPMC10684414 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature