Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies.

ABSTRACT: Chemicals infiltrate our daily experiences through multiple exposure pathways. Human biomonitoring (HBM) is routinely used to comprehensively understand these chemical interactions. Historically, HBM depended on targeted screening methods limited to a relatively small set of chemicals with triple quadrupole instruments typically. However, recent advances in high-resolution mass spectrometry (HRMS) have facilitated the use of broad-scope target, suspect, and non-target strategies, enhancing chemical exposome characterization within acceptable detection limits. Despite these advancements, establishing robust and efficient sample treatment protocols is still essential for trustworthy broad-range chemical analysis. This study sought to validate a methodology leveraging HRMS-based strategies fo

SUBMITTER: Gutierrez-Martin D 

PROVIDER: S-EPMC10684428 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature