Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model.

ABSTRACT: Fetal growth restriction (FGR) remains one of the main obstetrical problems worldwide, with consequences beyond perinatal life. Animal models with developmental and structural similarities to the human are essential to understand FGR long-term consequences and design novel therapeutic strategies aimed at preventing or ameliorating them. Herein, we described the long-term consequences of FGR in pulmonary function, structure, and gene expression, and characterized neurodevelopmental sequelae up to preadolescence in a rabbit model. FGR was induced at gestational day 25 by surgically reducing placental blood supply in one uterine horn, leaving the contralateral horn as internal control. Neonatal rabbits born near term were assigned to foster care in mixed groups until postnatal day (PND) 21. A

SUBMITTER: Valenzuela I 

PROVIDER: S-EPMC10684490 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature